Publications

ALD-R491 regulates vimentin filament stability and solubility, cell contractile force, cell migration speed and directionality

Hyejeong Rosemary Kim, Samantha Warrington, Ana López-Guajardo; Khairat Al Hennawi, Sarah L. Cook, Zak D. J. Griffith, Deebie Symmes, Tao Zhang; Zhipeng Qu, Ying Xu, Ruihuan Chen and Annica K. B. Gad. Frontiers in Cell and Developmental Biology, 22 November 2022

Hyaluronan nanoscale clustering and Hyaluronan synthase 2 expression are linked to the invasion of child fibroblasts and infantile fibrosarcoma in vitro and in vivo

Joseph J. Tonge, Scott V. Notley, Mark J. Dunning, Ana López-Guajardo, Jessica D. Medcalf, Paraskevi Heldin, George Panoutsos and Annica K. B. Gad. Scientific Reports, 18 November 2022

Effects of vimentin on the migration, search efficiency, and mechanical resilience of dendritic cells

Annica Gad, M. Reza Shaebani, Luiza Stankevicins, Doriane Vesperini, Marta Urbanska, Daniel A.D. Flormann, Emmanuel Terriac, Annica K.B. Gad, Fang Cheng and John E. Eriksson. Biophysical Journal, 18 October 2022

Hyaluronan nanoscale clustering and Hyaluronan synthase 2 expression are linked to the invasion of child fibroblasts and infantile fibrosarcoma in vitro and in vivo

Joseph J. Tonge, Scott V. Notley, Mark J. Dunning, Ana López-Guajardo, Jessica D. Medcalf, Paraskevi Heldin, George Panoutsos, Annica K. B. Gad. DOI: 10.21203/rs.3.rs-1403299/v1

Metastasising Fibroblasts Show an HDAC6-Dependent Increase in Migration Speed and Loss of Directionality Linked to Major Changes in the Vimentin Interactome

Caroline A. Evans, Hyejeong Rosemary Kim, Sarah C. Macfarlane, Poppy I. A. Nowicki, Carsten Baltes, Lei Xu, Jerker Widengren, Franziska Lautenschläger, Bernard M. Corfe and Annica K. B. Gad. International Journal of Molecular Sciences, 10 February 2022

The Fibrillar Matrix: Novel Avenues for Breast Cancer Detection and Treatment

Rasha Rezk, Raquel Marín-García and Annica K.B.Gad. Engineering, October 2021

A novel universal algorithm for filament network tracing and cytoskeleton analysis

Flormann DAD, Schu M, Terriac E, Thalla D, Kainka L, Koch M, Gad AKB and Lautenschläger F. FASEB journal, 9 April 2021

Vimentin provides target search efficiency and mechanical resilience for dendritic cell migration

Luiza Da Cunha Stankevicins, M. Reza Shaebani, Doriane Vesperini, Marta Urbanska, Daniel A. D. Flormann, Emmanuel Terriac, Annica K. B. Gad, Fang Cheng, John E. Eriksson and Franziska Lautenschläger. DOI: 10.1101/2020.12.18.423401

Vimentin Diversity in Health and Disease

Frida Danielsson, McKenzie Kirsten Peterson, Helena Caldeira Araújo, Franziska Lautenschläger and Annica Gad. Cells, 21 September 2018

Nanoscale localization of proteins within focal adhesions indicates discrete functional assemblies with selective force-dependence

Lei Xu, Laura J. Braun, Daniel Rönnlund, Jerker Widengren, Pontus Aspenström and Annica K. B. Gad. The FEBS journal, 14 March 2018

Vimentin Levels and Serine 71 Phosphorylation in the Control of Cell-Matrix Adhesions, Migration Speed, and Shape of Transformed Human Fibroblasts

Emmanuel Terriac, Giovanna Coceano, Zahra Mavajian, Tijmen A. G. Hageman, Andreas F. Christ, Ilaria Testa, Franziska Lautenschläger and Annica K. B. Gad. Cells, 22 January 2017

RhoA knockout fibroblasts lose tumor-inhibitory capacity in vitro and promote tumor growth in vivo

Twana Alkasalias, Andrey Alexeyenko, Katharina Hennig, Frida Danielsson, Robert Jan Lebbink, Matthew Fielden, S. Pauliina Turunen; Kaisa Lehti; Vladimir Kashuba; Harsha S. Madapura; Benedek Bozoky; Emma Lundberg; Martial Balland; Hayrettin Guvén; George Klein; Annica K. B. Gad; Tatiana Pavlova. PNAS, 7 February 2017

Experimental and computational assessment of F-actin influence in regulating cellular stiffness and relaxation behaviour of fibroblasts

Björn Fallqvist, Matthew L.Fielden, Torbjörn Pettersson, Niklas Nordgren, Martin Kroon and Annica K.B.Gad. J Mech Behav Biomed Mater, 18 December 2015

Resolution, target density and labeling effects in colocalization studies - suppression of false positives by nanoscopy and modified algorithms

Lei Xu, Daniel Rönnlund, Pontus Aspenström, Laura J. Braun, Annica K. B. Gad and Jerker Widengren. FEBS J, 12 January 2016

RhoD is a Golgi component with a role in anterograde protein transport from the ER to the plasma membrane

Magdalena Blom, Katarina Reis, Vishal Nehru, Hans Blom; Annica K. B. Gad and Pontus Aspenström. Exp. Cell Res., 5 March 2015

Analysis of Rho GTPase-induced localization of nanoscale adhesions using fluorescence nanoscopy

Annica K. B. Gad, Daniel Rönnlund, Jerker Widengren and Pontus Aspenström. Methods mol. biol., 26 December 2013

Multicolor fluorescence nanoscopy by photobleaching: Concept, verification, and its application to resolve selective storage of proteins in platelets

Daniel Rönnlund, Lei Xu, Anna Perols, Annica K. B. Gad, Amelie Eriksson Karlström, Gert Auer and Jerker Widengren. ACS Nano, 14 April 2014

Oncogenes induce a vimentin filament collapse mediated by HDAC6 that is linked to cell stiffness

Li-Sophie Z. Rathje, Niklas Nordgren, Torbjörn Pettersson, Daniel Rönnlund, Jerker Widengren, Pontus Aspenström and Annica K. B. Gad. PNAS, 13 January 2014

Transient state microscopy probes patterns of altered oxygen consumption in cancer cells

Thiemo Spielmann; Lei Xu, Annica K. B. Gad, Sofia Johansson and Jerker Widengren. FEBS J., 13 January 2014

Majority of differentially expressed genes are down-regulated during malignant transformation in a four-stage model

Frida Danielsson; Marie Skogs; Mikael Huss; Elton Rexhepaj; Gillian O’Hurley; Daniel Klevebring; Fredrik Pontén; Annica K. B. Gad; Mathias Uhlén and Emma Lundberg. PNAS, 8 April 2013

Nurture your scientific curiosity early in your research career

Maja Jagodic; Pernilla Stridh; Annica K B Gad; Ananta Paine; Klas I Udekwu; Louise K Sjöholm; Mattias Svensson and Qiang Pan-Hammarström. Nature Genetics, 29 January 2013

Spatial organization of proteins in metastasizing cells

Daniel Rönnlund; Annica K. B. Gad; Hans Blom; Pontus Aspenström and Jerker Widengren. Cytometry A, 08 May 2013

Rho GTPases link cellular contractile force to the density and distribution of nanoscale adhesions

Annica K. B. Gad; Daniel Rönnlund; Alexander Spaar; Andrii A. Savchenko; Gabor Petranyi; Hans Blom; Laszlo Szekely; Jerker Widengren and Pontus Aspenström. FASEB J, 27 February 2012

RhoD regulates cytoskeletal dynamics via the actin nucleation-promoting factor WASp homologue associated with actin Golgi membranes and microtubules

Annica K. B. Gad; Vishal Nehru; Aino Ruusala and Pontus Aspenström. Molecular Biology of the Cell, 19 October 2012

Rif proteins take to the RhoD: Rho GTPases at the crossroads of actin dynamics and membrane trafficking

Annica K.B.Gad and Pontus Aspenström. Cell. Signal., 8 October 2009

Plectin deposition at podosome rings requires myosin contractility

Annica Gad; Sibylle Lach; Luca Crimaldi and Mario Gimona. Cell motil. cytoskelet, 13 June 2008

Oncogenic H-Ras V12 promotes anchorage-independent cytokinesis in human fibroblasts

Minna Thullberg; Annica Gad; Sylvie Le Guyader and Staffan Strömblad. PNAS, 18 December 2007

The kinase-inhibitory domain of p21-activated kinase 1 (PAK1) inhibits cell cycle progression independent of PAK1 kinase activity

M Thullberg; A Gad; A Beeser; J Chernoff and S Strömblad, Oncogene, 25 September 2006

Recombinant CD44-HABD is a novel and potent direct angiogenesis inhibitor enforcing endothelial cell-specific growth inhibition independently of hyaluronic acid binding

Taavi Päll; Annica Gad; Lagle Kasak; Monika Drews; Staffan Strömblad and Priit Kogerman. Oncogene, 13 September 2004

Retinoblastoma Susceptibility Gene Product (pRb) and p107 Functionally Separate the Requirements for Serum and Anchorage in the Cell Cycle G 1-phase

AnnicaGad; MinnaThullberg; Jan-Hermen Dannenberg; Hein te Riele and Staffan Strömblad. J. Biol. Chem., 19 January 2004

RANTES promotes growth and survival of human first-trimester forebrain astrocytes

Moiz Bakhiet; Annelie Tjernlund; Alyaa Mousa; Annica Gad; Staffan Strömblad; William A. Kuziel; Åke Seiger and Jan Andersson. Nat. Cell Biol., 15 January 2001