TUMOUR CELL MECHANOBIOLOGY
Welcome to the research group of Dr. Annica K. B. Gad!
Why are tumors mechanically different from normal tissue? What controls the mechanical and physical properties of cells in cancer? Which molecules induce cell migration and metastasis, the main cause of cancer death? Why do most people not, and some animals never, develop cancer? What protects us and keeps us healthy?
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We are a diverse and inclusive group (Team) who aims at understanding the molecular mechanisms that regulate the mechanical and spatial aspects of cancer, for future development of novel methods for therapies and diagnosis against cancer. We pursue hypothesis- and collaboration-based interdisciplinary research, that, mainly fall into the four following categories:
Mechanobiology of fibroblasts
i.e. cell-matrix adhesion, contractile forces, stiffness, shape and motility
Cancer-associated fibroblasts in triple negative breast cancer
Vimentin in cancer
a cytoplasmic, cytoskeletal intermediate filament protein